Monitor New LHON Publications and News

Background

LHON research is moving rapidly, with gene therapies progressing through clinical trials and the 2026 TALED gene-editing breakthrough opening new avenues. Keeping track of all new publications, trial updates, and regulatory decisions is critical for the community but time-consuming for individual researchers or patients.

What Needs to Be Done

Create a comprehensive digest of all LHON-related developments in 2026:

1. New publications — Search PubMed for papers published in 2026 mentioning LHON, Leber Hereditary Optic Neuropathy, or related terms (MT-ND4, MT-ND1, mitochondrial optic neuropathy)
2. Clinical trial updates — Check ClinicalTrials.gov for new registrations, status changes, or published results
3. News and press releases — Search for media coverage of LHON treatments, company announcements, or patient advocacy news
4. Regulatory updates — Check FDA and EMA databases for any LHON-related decisions

Why This Matters

A well-maintained publication digest ensures no important development goes unnoticed. It’s especially valuable for patients and families tracking treatment progress, and for researchers staying current across the field.

How to Submit

Submit your results by opening a GitHub issue with the label monitor-publications. Include your chronological digest with links to all sources.