Seoul National University Base Editing Team
Seoul National University College of Medicine
Published breakthrough on DdCBE (dual-deaminase base editor) for mitochondrial DNA correction in Nature Communications (Nov 2025). Represents the most advanced preclinical approach to directly correcting LHON mutations rather than replacing gene expression.
Research focus
Public profiles
- Institution: https://medicine.snu.ac.kr/en/
Contact is made via official institutional channels, not private email. To request removal, email the project.
Relevant project findings
The SNU team’s base editing approach is fundamentally different from existing AAV2-based gene therapies — it corrects the underlying mtDNA mutation rather than introducing a functional copy of the gene. If it advances to clinical trials, it could be transformative. Currently preclinical but positioned for first-in-human trials within 2-4 years.
Project outreach status
Not yet contacted